To reduce the risk of withdrawal, patients should wait at least 7 days after their last short-term opioid administration and 10 to 14 days for long-acting opioids before starting to use naltrexone. Patients taking naltrexone should not use other opioids or illicit drugs; Drinking alcohol or take tranquilizers, tranquilizers or other drugs. Patients should inform their doctor of all medications they are currently taking, as well as changes to medications while they are being treated with naltrexone. Although oral formulation also blocks opiate receptors, only long-term injection formulation is licensed by the FDA as MAT and requires REMS. Patients should talk to their doctor before starting naltrexone treatment on the following situations: Eliminate unused naltrexone safely. Please contact your MAT doctor for advice or for more information on the safety of eliminating unused drugs, visit the FDA for unused drugs or the DeA website for drug elimination. Conclusions: These factors help to study the efficacy and safety of the combination of acamprosate and naltrexone in the treatment of alcohol dependence in a large-scale multisite study with evaluation of potential predictors for response to each drug alone and in combination with placebo. Patients with naltrexone who interrupt administration or relapse after a period of abstinence may have reduced tolerance to opioids. As a result, taking identical or even lower doses of opioids used in the past can have fatal consequences.
These are not all the side effects of naltrexone. For more information, patients should speak to their doctor or pharmacist. Patients should consult their doctor about side effects that are annoying, or not go away. Results: Pharmacokinetic and pharmacodynamic studies indicate an increase in plasma concentrations of acamprosate without clinically significant increase in adverse events when the two drugs are used in combination. Data from dose-effect studies on acamprosates alone suggest that increased plasma concentrations of acamprosate by concomitant naltrexone administration may have clinical benefits. Objective: This article provides an evidence-based review of acamprosate and naltrexone, used alone and in combination. Both drugs are increasingly available worldwide through prescription for the treatment of alcohol dependence. There is scientific and clinical interest in the study of these drugs in combination, given their high tolerance, moderate efficacy, different pharmacological profiles and potentially different effects on alcohol outcomes.